报告题目：Beyond Radiation Induced DNA Double Strand Breaks - a New Horizon for Radiation Therapy Research

报告人：常小莎终身副教授

（北卡罗来纳大学医学院，放射肿瘤学）

时间：2016年8月19日（星期五）下午2:30

地点：苏州大学独墅湖校区402幢一楼会议室

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            欧洲杯官网

摘要：

Most of the advancements made in the past two decades in cancer radiation therapy are largely based on the fundamental hypothesis that radiation causes cell death and thus tumor control or normal tissue toxicity through DNA double strand breaks. However, new research have challenged the hypothesis and elucidated that in addition to causing cellular DNA damage, localized radiation also initiates cascades of complex downstream biological responses in tissue that extend far beyond where radiation dose is deposited and beyond cell killing. The new multidisciplinary research show that massive radiation dose may not lead to normal organ function damage as long as the radiation is finely fractionated in space; locally irradiated dying tumor cells may release tumor antigens to enhance systemic anti-cancer immune response in cancer patient; targeted irradiation to solid tumor may increase the migration of tumor cells in bloodstream, the seeds of potential metastasis; and microbeam radiation significantly modulated tumor microvasculature and that can be used to drastically enhance tumor delivery of nanoparticle-encapsulation cancer drugs.