题目：Cutting Edge Strategies in Fluorescent Imaging For Future Biomedical Applications
报告人：Xing Bengang教授
时间：07月25日（周六）下午02:00
地点：401号楼一楼会议室
报告摘要：
Biological specificity is mediated by the precise and selective regulation of protein ad enzyme functions in response to intrinsic development programs and extrinsic signals. In order to fully understand the protein or enzyme functions and further elucidate their mechanisms in biology, it is essential to apply a simple and reliable assay with high sensitivity and fidelity that can efficiently report the biological process of interest at the single cell or molecular level. In general, fluorescent imaging techniques enable rapid, direct and sensitive visualization of biological events at single cell or molecule resolution because of their high sensitivity, relative safety, and easily handling, and therefore have become robust and reliable tools in monitoring subcellular protein dynamics and analysis of tumors or pathogen–host interactions. The systematic studies of chemical reactions of enzyme or proteins with the fluorescence conjugated substrates in a complicated environment will offer the great possibility for the in-depth understanding of the biological basis conferring diseases status, and importantly, for the facilitating of new discovery and development of effective therapeutic and diagnostic approaches in vitro and in vivo. In our group, a series of simple and specific fluorescent/bioluminescent probes have been developed to real-time visualize bacterial or tumor cell functions, importantly, the intrinsic mechanisms to involve in potent drug activities and relevant pathways to potentially initiate drug resistance have been extensively investigated in vitro and in vivo.
报告人简介：
Bengang Xing, Associate Professor, Assistant Chair (Academic) School of Physical & Mathematical Sciences, Deputy Head, Division of Chemistry and Biological Chemistry, NTU, Singapore.
Research interests: Biomedical Fluorescent Imaging, Chemical Biology, Nano-medicine
Employment History
2011-nowAssociate Professor, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore
2006-2011Assistant Professor, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore
2004-2006Post-doc Research Fellow: Molecular Imaging Program, School of Medicine, Stanford University, USA
2003-2004Research Associate: Molecular Imaging Program, School of Pharmacology, UCLA, USA
2001-2003Research Associate, The Hong Kong University of Science and Technology, Hong Kong
Academic Qualifications:
2000Ph.D., Bio-Inorganic Chemistry, Nanjing University, China
1994B.Sc., Chemistry education, Xinjiang Normal University, China
5 most relevant publications in the last 5 years that pertains to the proposed programme
1. J. Mu, F. Liu, M. S. Rajab, M. Shi, S. Li, C. Goh, L. Lu, Q. Xu, B. Liu, L. G. Ng, B. G. Xing* “Small-Molecule FRET Reporter for Real-Time Visualization of Cell-Surface Proteolytic Enzyme Functions” Angew Chem. Intl. Ed., 2014, 53, 14357.
2. A. Abbas, B. G. Xing*, T. P. Loh*, “Allenamides as Orthogonal Handle for Selective Modification of Cysteine in Peptides and Proteins,” Angew Chem. Intl. Ed. 2014. 53, 7491.
3. Y. M. Yang, Q. Shao, R. Deng, C. Wang, X. Teng, K. Cheng, Z. Cheng, L. Huang, Z. Liu, and X. G. Liu*, B. G. Xing*. “In Vitro and In Vivo Uncaging and Bioluminescence Imaging through Photocaged Upconversion Nanoparticles.” Angew. Chem. Int. Ed., 2012, 51, 3125-3129. Selected as “hot paper” and “Inside cover” in Angew chem.
4. Y. Min, J. Li, F. Liu, E. K. L. Yeow*, B. G. Xing* “Near-Infrared Light Mediated Photoactivation of Platinum Antitumor Prodrug and Simultaneous Cellular Apoptosis Imaging via Upconversion Nanoparticles” Angew Chem. Intl. Ed. 2014. 53, 1012.
5. “A Simple and Specific Assay for Real Time Colorimetric Visualization of Beta-Lactamase activity by Using Gold Nanoparticles.” R. R. Liu; R. S. Liew; J. Zhou; B. G. Xing*. Angew. Chem. Int. Ed. 46, 8799-8803, 2007.
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