报告题目1：Layered double hydroxide nanoparticle-based efficient delivery platform
报告人：Zhi Ping (Gordon) Xu
报告时间：2015年6月29日下午2:30
报告地点：欧洲杯官网会议室（401一楼会议室）
报告题目2：Advanced Materials for light emitting and absorption applications
报告人：Shih-Chun Lo
报告时间：2015年6月29日下午3:30
报告地点：欧洲杯官网会议室（401一楼会议室）
欢迎广大师生踊跃参加！
医学部欧洲杯官网
放射医学及交叉学科研究院
附：报告摘要
Layered double hydroxide nanoparticle-based efficient delivery platform
Zhi Ping (Gordon) Xu
Australian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia. Email: gordonxu@uq.edu.au
Layered double hydroxides (LDHs), also known as anionic clays and exemplified by hydrotalcite (Mg6Al2(OH)16CO3×4H2O), find a high potential as the drug/gene/antigen delivery vehicle. In this talk, I will report our findings that LDH NPs can be quickly taken up by various cell lines, in a clathrin-mediated dose-dependent and time-dependent endocytosis pathway.
In this talk, I will then present two examples to demonstrate the feasibility using LDH NPs as delivery vehicles. One example is anti-restenotic drug delivery. Low molecular weight heparin (LMWH) is a good and commonly used anti-restenotic drug to intervene the biological activity of vascular smooth muscle cells (SMCs). Intercalation of LMWH into LDH enables the release to sustain for over 5 days. More significantly, LMWH-LDH nanohybrids enhance the inhibition to SMC proliferation and migration by ~60% compared with the control, e.g. promoting the biological functions of LMWH on SMCs.
The second example is delivery of functional small interfering RNA (siRNA) and its DNA mimic to various cell lines, with the efficiency superior to the commercial polymeric vehicle. We have also found that the co-delivery of anti-cancer drug and siRNA using LDH as the vehicle synergises the inhibition of cancers.
The promising in vitro results drive my research into the in vivo applications. However, LDH-drug hybrids aggregate in the blood, resulting in severe inflammatory responses or even death. Thus we have developed albumin pre-coating strategy to prevent LDH or LDH-drug nanoparticles from aggregation in phosphate buffer saline and cell culture medium solutions. The albumin pre-coating does not affect cellular uptake of LDH nanoparticles in Chinese hamster ovary cell culture. Some in vivo experimental tests are now under way to treat tumours.
Advanced Materials for light emitting and absorption applications
Shih-Chun Lo (羅世鈞)
Centre for Organic Photonics & Electronics, School of Chemistry & Molecular Biosciences,
The University of Queensland, Brisbane, QLD 4072, Australia
Email: s.lo@uq.edu.au
http://staff.scmb.uq.edu.au/staff/shih-chun-lawrence-lo
http://researchers.uq.edu.au/researcher/1998
Luminescent chromophores have been playing a major technological role in many important applications such as organic and inorganic light emitters for flat panel and flexible displays1 as well as wide potential in the fields of optical devices and biomedicine such as high-resolution 3D imaging and deep tissue treatment. Among the numerous luminescent chromophores developed such as fluorescent proteins, organic dyes metal complexes, semiconductors, metal nanoparticles, Pt(II) and Ir(III) complexes have been intensively studied as they exhibit many desirable properties, such as high thermal, electrochemical and photo-stability with high photoluminescence quantum yields and short-excited state lifetime that are suitable for light emitting application.2 Due to their unique nature of excitions, their emission colours are highly tunable, covering whole visible range through molecular engineering.
In this presentation, effective strategies toachieve highly efficient phosphorescence in particular deep blue phosphorescence will be described as a common problem is that when the emission shifts to deeper blue, the luminescent efficiency significantly decreases 3 due to the dwindling admixture of the metal-to-ligand charge transfer (MLCT) transition, coupled with fast non-radiative decay rates.4 The relationship between their chemical structures and emission, thermal, electrochemical and photophysical properties will be also discussed.
The presentation will also discuss some other high efficient light-emitting dyes as well as new organic chromophores, enabling to absorb visible light with efficient photoresponse for light sensing and imaging.
References:
1. a) C. W. Tang, et al. Appl. Phys. Lett. 1987, 51, 913. b) J. H. Burroughes, et al. Nature 1990, 347, 539. c) S. R. Forrest, Nature 2004, 428, 911. d) A. C. Grimsdale, et al. Chem. Rev. 2009, 109, 897. e) S.-C. Lo, et al. Chem. Rev. 2007, 107, 1097. f) L. Zhou, et al. ACS Nano 2014, 8, 12796. g) A. Asadpoordarvish, et al. Adv. Funct. Mater. 2015, 25, 3238.
2. a) M. A. Baldo, et al. Nature, 2000, 403, 750. b) M. K. Nazeeruddin, et al. J. Am. Chem. Soc. 2003, 125, 8790. c) K. Dedeian, et al. Inorg. Chem. 2007, 46, 1603. d) S.-C. Lo, et al. J. Am Chem. Soc. 2009,131, 16681.
3. S.-C. Lo, et al. Chem. Mater. 2006, 18, 5119.
4. R. E. Harding, et al. Org. Electron. 2008, 9, 377.