学术报告

主题：Loss of DAB2IP function linked to radiation resistance of prostate tumors

报告人： Debabrata Saha教授

时间：10月14日上午9时

地点：402号楼一层会议室

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报告摘要：DAB2IP (DOC-2/DAB2 interactive protein) is a member of the RAS-GTPase-activating protein family. It is often downregulated in metastatic prostate cancer and has been reported as a possible prognostic marker to predict the risk of aggressive prostate cancer. Our studies revealed that DAB2IP plays a significant role in prostate cell survival following IR exposure due to enhanced DSB repair, robust G(2)-M checkpoint control, and resistance to IR-induced apoptosis. Therefore, it is important to identify patients with dysregulated DAB2IP for (a) assessing prostate cancer risk and (b) alternative treatment regimens.

报告人简介：

Debabrata Saha, assistant Professor, Department of Radiation Oncology, UT Southwestern Medical Center at Dallas.

Education: Ph.D., 1997, Chemistry, University of Nebraska, Lincoln, USA; M.S., 1991, Biochemistry, University of Calcutta, West Bengal, India; B.S., 1988, Chemistry, University of Calcutta, West Bengal, India.

Research Interests: Role of small molecule inhibitors as radio- and chemo-sensitizers; Genomic Instability and Cancer Development; Radiation Biology and DNA Damage Repair