Title: The RP-Mdm2-p53pathway in metabolic control and cancer prevention（RP-Mdm2-p53信号通路与代谢调控和癌症预防）
Speaker: Yanping Zhang（张延平）, Ph.D., Professor（University of North Carolina at Chapel Hill, Chapel Hill, NC,USA）
时间：2014年5月21日（周三）下午1：00
地点：学院三楼会议室
Time: 13:00, 21st May, 2014
Place: 3rd floormeeting room
Host: Dr. GengLiu（刘赓）
Abstract: One ofthe most energetically demanding functions of cellular growth and division isribosome biogenesis. Perturbations to ribosome biogenesis have beendemonstrated to induce an acute stress response leading to p53 activationthrough the inhibition of Mdm2 by a number of ribosomal proteins. I willdiscuss the known functions of p53 to postulate how changes in nutrientavailability may induce the ribosomal protein-Mdm2-p53 signaling pathway tomodulate p53-dependent metabolic regulation.
Yanping Zhang (张延平), Ph.D., Professor
Department of RadiationOncology and Lineberger Comprehensive CancerCenter, School of Medicine, the University of North Carolinaat Chapel Hill, Chapel Hill, NC,
Education:
1997-00 Postdoctoral Fellow, LinebergerCancer Center,UNC Chapel Hill
1992 Ph.D, Molecular Biology, University of Nebraskaat Lincoln, Nebraska.
1985 M.S., Virology, Fudan University,Shanghai,
1982 B.S., Microbiology, FudanUniversity, Shanghai,
Professional Experience:
2010- Professor, Universityof North Carolina at Chapel Hill.
2007-10 Associate Professor, Universityof North Carolina at Chapel Hill.
2004-06 Assistant Professor, Universityof North Carolina at Chapel Hill.
2001-04 AssistantProfessor, U.T. M.D. AndersonCancer Center,Houston.
1997-00 Postdoctoral Fellow, LinebergerCancer Center,UNC Chapel Hill.
1993-96 VP and Co-Founder, Megabase Research Products, Lincoln, Nebraska.