王广林 硕士生导师 副教授
国家重点研发专项子课题负责人
江苏省优秀青年基金获得者
电子邮箱：glwang[AT]suda.edu.cn
通讯地址：苏州工业园区仁爱路199号, 邮编215123
先后主持国家重点研发专项项目子课题1项，基金委材料学部青年基金1相，基金委化学部面上项目1项，江苏省自然科学基金青年和优秀青年基金项目各1项，安徽省自然科学基金面上项目1项；同时跟企业合作横向课题5项开发放射性药物。2016年获苏州市高层次紧缺人才。2013年和2017年两次获得International Symposium on Targeted Alpha Therapy的Travel Award。2022年指导本科生参加江苏省生物医学工程竞赛获一等奖。截止目前，在ACS Appl. Mater. Interfaces, Biomaterials Science等学术期刊上共发表学术论文30余篇。
学习经历：
2001-2005年安徽大学高分子材料与工程系 本科
2006-2009年中国科学技术大学同步辐射国家实验室 硕士（导师：李良彬教授）
2009-2014年荷兰代尔夫特理工大学反应堆研究所 博士（导师: H. Th. Wolterbeek教授）
研究方向：
放射性核素标记方法的研究
放射性核素标记用于药物药代动力学研究
放射性标记药物在肿瘤诊断和治疗中的应用研究
代表性论文：
1. Imaging-Guided Targeted Radionuclide Tumor Therapy: From Concept to Clinical Translation,
Juan Sun, Zhenyuan Huangfu, Jiangtao Yang, Guanglin Wang*, Kuan Hu*, Mingyuan Gao, Zhiyuan Zhong*.
Advanced Drug Delivery Reviews, 2022, 190, 114538.
2. Acidity-Activated Charge Conversion of 177Lu-Labeled Nanoagent for the Enhanced Photodynamic Radionuclide Therapy of Cancer
Yuan Zhang#, Guanglin Wang#, Qing Li*, Yue Jiang, Wan Chen, Min Zhao, Gaolin Liang, Qingqing Miao*
ACS Appl. Mater. Interfaces 2022, 14, 3, 3875–3884.
3.Facile Preparation of 177Lu-microspheres for Hepatocellular Carcinoma Radioisotope Therapy
Manran Wu, Kexin Shi, Ruizhe Huang, Chunyi Liu, Lingling Yin, Weipeng Yong, Jing Sun, Guanglin Wang*, and Mingyuan Gao*
Chinese Chemical Letter, 2022, 33, 3492-3496.
4. Redox-sensitive iodinated polymersomes carrying histone deacetylase inhibitor as a dual-functional nano-radiosensitizer for enhanced radiotherapy of breast cancer，
Zhehong Zhu, Manran Wu, Juan Sun, Zhengyuan Huangfu, Lingling Yin, Weipeng Yong, Jing Sun, Guanglin Wang*, Fenghua Meng, Zhiyuan Zhong*,
Drug Delivery,2021, 28, 2301-2309.
5. Sequential SPECT and NIR-II imaging of tumor and sentinel lymph node metastasis for diagnosis and image-guided surgery.
Xiaolu Zhang#, Meng Zhao#, Ling Wen#, Manran Wu, Yi Yang, Yujuan Zhang,Yan Wu, Jian Zhong*, Haibin Shi, Jianfeng Zeng, Guanglin Wang* andMingyuan Gao*
Biomaterials Science, 2021, 9, 3069.
6. Iodine-rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor In Vivo
Jinsong Cao, Yaohua Wei, Yanxiang Zhang, Guanglin Wang*, Xiang Ji, and Zhiyuan Zhong*
ACS Appl. Mater. Interfaces, 2019, 11, 18953-18959.
7. Pharmacokinetics of Polymersomes Composed of Poly(butadiene-ethylene oxide); Healthy vs. Tumor Bearing Mice
Guanglin Wang, R. M. de Kruijff, D. Abou, N. Ramos, E. Mendes, L. E. Franken, H. T. Wolterbeek, and A. G. Denkova*
J. Biomed. Nano., 2016, 12, 320-328.
8.Enhanced Retention of Encapsulated Ions in Cross-Linked Polymersomes
Guanglin Wang, A. Hoornweg, H Th. Wolterbeek, L. Franken, E. Mendes, and A. G. Denkova*
J. Phys. Chem. B, 2015, 119(11), 4300-4308.
9. Retention Studies of Recoiling Daughter Nuclides of 225Ac in Polymer Vesicles
Guanglin Wang, R.M. de Kruijff, A. Rol, L. Thijssen, E. Mendes, A. Morgenstern, F. Bruchertseifer, M.C.A. Stuart, H.Th. Wolterbeek, and A.G. Denkova*
Appl. Radiat. Isotopes, 2014, 85, 45-53.
10. Polymersomes as Radionuclide Carriers Loaded via Active Ion Transport through the Hydrophobic Bilayer
Guanglin Wang, R. de Kruijff, M. C. A. Stuart, E. Mendes, H. T. Wolterbeek, and A. G. Denkova*
Soft Matter, 2013, 9, 727.
