Guangming Zhou, PhD
Professor, School of Radiation Medicine and Protection, Soochow University,
Suzhou 215123, China
Tel: 86-512-65880052, Fax: 86-512-65884830
E-mail: gmzhou@suda.edu.cn
Education Background:
PhD in Particle Physics and Nuclear Physics, University of Chinese Academy of Sciences, China, 2001
BSc in Biochemistry, Lanzhou University, China, 1994
Professional Experience:
2015---: Professor in Radiobiology, School of Radiation Medicine and Protection, Soochow University, China
2007---2015: Professor in Biophysics, director of the Department of Space Radiobiology, Institute of Modern Physics, Chinese Academy of Sciences, China
2007---2005: Post-doc, Center for Radiation Research, Columbia University, USA
2003---2005: Post-doc, Biology Department, Brookhaven National Laboratory, USA
2002---2003: Visiting Scholar, School of Radiation Medicine, Chiba University, Japan
2001---2003: Assistant Professor, Institute of Modern Physics, Chinese Academy of Sciences, China
Research Interests:
Biological effects of heavy ion beam
Biogenesis of cancer stem cells induced by ionizing radiation
Functions of radiation-inducible non-coding RNAs
Development of anti-radiation drugs
Research Experience and Accomplishments:
1. Elucidated a novel mechanism of cellular radiosensitivity, namely cell cycle suspension and consequent G2 slippage.
2. Identified 10 kinds of novel microRNAs and experimentally revealed a microRNA-protein network regulating radiobiological effects induced by ionizing radiation.
3. Studied the radiobiological effects of various kinds of heavy particles and secondary radiation.
4. Developed a free radical scavenger.
Recent Publications (*Corresponding author):
1. Hu W, Xu S, Yao B, Hong M, Wu X, Pei H, Chang L, Ding N, Gao X, Ye, C, Wang J, Hei TK and Zhou G*. 2014, miR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode. RNA Biology, 11(9): 1189-1198.
2. Liu T, Pei H, Xu D, Zhang Y, Wan J, Wu X, Zhang X, Sun F, He J, Li P, Tian L, Wang J, Chen W, Zhou G*. 2014, GANRA-5 protects mice from X-ray irradiation-induced dysfunction of immune system. Free Radical Research, 48(8): 875-882
3. Pei H, Chen W, Hu W, Zhu M, Liu T, Wang J and Zhou G*. 2014, GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger. Free Radical Research, 48(6): 670-678.
4. Zhang H, Sun Z, Wei W, Liu Z, Fleming J, Zhang J, Lin N, Wang M, Chen M, Xu Y, Zhou J, Li C, Bi L, Zhou G*. 2014, Identification of serum microRNA biomarkers for tuberculosis using RNA-seq. PLoS ONE, 9(2): e88909.
5. Hu W, Pei H, Ding N, He J, Wang J, Furusawa Y, Hirayama R, Matsumoto Y, Liu C, Kawata T, Zhou G*. 2014, Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures. Journal of Radiation Research, 55(1): 10-16.
6. Wang J, He J, Su F, Ding D, Hu W, Yao B, Wang W, and Zhou G*. 2013, Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death and Disease, 4: e699.
7. Ye C, Zhang X, Wan J, Chang L, Bing Z, Zhang S, Li J, He J, Wang J*, Zhou G*. 2013, Long-term G2-arrested cells exposed to ionizing radiation undergo cellular senescence via slipping into the G1 phase. Cell Cycle, 12(9): 1424-1432.
8. Ding N, Pei H, He J, Furusawa Y, Hirayama R, Liu C, Matsumoto Y, Li H, Hu W, Li Y, Wang J, Wang T, Zhou G*. 2013, Simulated studies on the biological effects of space radiation on quiescent human fibroblasts. Advances in Space Research, 52: 1314-1319.
9. Wang F, Bing Z, Zhang Y, Ao B, Zhang S, Ye C, He J, Ding N, Ye W, Xiong J, Sun J, Furusawa Y, Zhou G*, and Yang L. 2013, Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line. Journal of Radiation Research, 54(4): 649-62.
10. Chang L, Hu W, Ye C, Yao B, Song L, Wu X, Ding N, Wang J, and Zhou G*. 2012, miR-3928 activates ATR pathway by targeting dicer. RNA Biology, 9(10): 1247-1254.
11. He J, Li J, Ye C, Zhou L, Zhu J, Wang J, Mizota A, Furusawa Y, and Zhou G*. 2011, Cell cycle suspension: A novel process lurking in G2 arrest. Cell Cycle, 10(9): 1468-1476.
12. Wang J, Su F, Smilenov LB, Zhou L, Hu W, Ding N, and Zhou G*. 2011, Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity. Radiation Oncology, 6: 96.
13. Ding N, Wu X, He J, Chang L, Hu W, Li W, Wang J, Wang T, and Zhou G*. 2011, Detection of novel human miRNAs responding to X-ray irradiation. Journal of Radiation Research, 52: 425-432.
14. Zhou G, Smilenov LB, Lieberman HB, Ludwig T, Hall EJ. Radiosensitivity to high energy iron ions is influenced by heterozygosity for ATM, RAD9 and BRCA1. 2010, Advances in Space Research, 46: 681-686
Honors and Awards:
2010, Collaboration and Multidisplinary Team of the Chinese Academy of Sciences
2008, Hundred Talent Program of the Chinese Academy of Sciences
Contact Information：
Address: 199 Renai Road, Suzhou 215123, China
Cell: 86-13914058572
Email: gmzhou@suda.edu.cn