Haibin Shi, PhD

Professor, School of Radiological and Interdisciplinary Science (RAD-X),

School of Radiation Medicine and Protection, Medical College of Soochow University，

Suzhou，Jiangsu，215006，China

Tel: 86-512-65882973

E-mail: hbshi@suda.edu.cn

Education Background:

PhD in Chemical Biology, National University of Singapore, Singapore, 2012

MSc in Chemistry, Soochow University, China, 2006

BSc in Chemistry, Yanbei Normal University, China, 2003

Professional Experience:

2014---now: Professor, School of Radiation Medicine and Protection, Soochow University, China

2012---2014: Postdoc Fellow, Department of Radiology, Stanford University, USA
2011---2012: Research Associate, Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
2010---2011: Research Associate, Department of Chemistry, National University of Singapore, Singapore

Research Interests:

My research interests mainly focus on (1) Development of smart probes for specific detection of disease-related enzymes; (2) Developing multifunctional probes for multimodal imaging and theragnosis; (3) Design, high-throughput synthesis and screening of drug candidates.

Research Experience and Accomplishments:

Professor Shi is currently working in School of Radiation Medicine and Protection. He received his B.Sc. from Yanbei Normal University (China) in 2003 and M.S. from Soochow University (China) in 2006. He completed his Ph D study in National University of Singapore (NUS) from 2006 to 2011. His PhD research involved bioorganic chemistry and design of small molecule probes for biological application, working under the supervision of Prof. Yao Shao Qin. After graduation, he worked in Prof Liu Bin’s lab (NUS) for one year as research associate. He then carried out his post-doctoral research at Stanford University (USA) under the supervision of Prof. Rao Jianghong from 2012 to 2014. To date, he has published total 22 decent papers in top journals (JACS, Angew. Chem., Chem. Commun etc). He was the first author on 13 of them. Total citation time is around 450.

Recent Publications:

1. Shi, H.; Cheng, Y, F.; Lee, K. H.; Luo, R. F.; Banaei, N.; Rao, J*. H. Engineering Stereochemistry of Cephalosporin for Specific Detection of Metallo-β-Lactamase-Expressing Pathogenic Bacteria. Angew. Chem. Intl. Ed. 2014, 53, 8113–8116. (IF = 11.33)

2. Shi, H.; Ryan, K. T. K.; Tang, B. Z*.; Liu, B*. Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics. J. Am. Chem. Soc. 2012, 134, 17972–17981. (IF = 11.44)

3. Shi, H.; Liu, J.; Geng, J.; Tang, B. Z*.; Liu, B*. Specific Detection of Integrin αVβ3 by Light-Up Bioprobe with Aggregation-induced Emission Characteristics. J. Am. Chem. Soc. 2012, 134, 9569–9572. (Highlighted in JACS Image Challenge and identified as highly cited paper in Essential Science Indicators) (IF = 11.44)

4. Shi, H.; Zhang, C.; Chen, G.Y.J.; Yao, S. Q*. Cell-Based Proteome Profiling of Potential Dasatinib? Targets Using Affinity-Based Probes (AfBPs). J. Am. Chem. Soc. 2012, 134, 3001–3014. (IF = 11.44)

5. Shi, H.; Cheng, X.; Sze, S.K.; Yao, S. Q*. Proteome Profiling Reveals Potential Cellular Targets of Staurosporine Using a Clickable Cell-Permeable Probe. Chem Comm, 2011, 47, 11306–11308. (IF = 6.72)

6. Shi, H.; Liu, K.; Xu, A.; Yao, S. Q*. Small Molecule Microarray (SMM)-facilitated Screening of Affinity-based Probes (AfBPs) for g-secretase. Chem. Commun. 2009, 5030–5032. (IF = 6.72)

7. Shi, H.; Uttamchandani, M.; Yao, S. Q*. Applying Small Molecule Microarrays and Resulting Affinity Probe Cocktails for Proteome Profiling of Mammalian Cell Lysates. Chem. -Asian. J. 2011, 6, 2803–2815. (IF = 3.94)

8. Shi, H.; Zhao, N.; Ding, D.; Liang, J.; Tang, B. Z*.; Liu, B*. In Vivo Imaging of Cell Apoptosis Using Fluorescent Light-Up Probe with Aggregation-Induced Emission Characteristics, Org. Biomol. Chem. 2013, 11(42), 7289–7296. (IF = 3.49)

9. Shi, H.; Wang, G.; Liang, J.; Liu, B*. Fluorescence turn-on detection of live cell apoptosis using a hyperbranched conjugated polyelectrolyte. Med. Chem. Commun. 2013, 4, 554–558. (IF = 2.63)

10. Shi, H.; Liu, K.; Leong, W. Y. W.; Yao, S. Q*. Expedient Solid-Phase Synthesis of Both Symmetric and Asymmetric Diol Libraries Targeting Aspartic Proteases. Bioorg. Med. Chem. Lett. 2009, 19, 3945–3948. (IF = 2.33)

11. Shi, H.; Ji, S*,; Bian, B. Studies on Transition Metal Ions Recognition Properties of 1-(2-benzothiazole)-3-(2-thiophene)-2-pyrazoline Derivatives. Dyes and Pigments, 2007, 73(3), 394–396. (IF = 3.47)

12. Shi, H.; Ji, S*.; Zhang, Y. Synthesis and Crystal Structures of Pyrazoline Derivants. Chinese Journal of Structural Chemistry. 2005, 24(5), 586–590. (IF = 0.48)

13. Ji, S*.; Shi, H. Synthesis and Fluorescent Property of Some Novel Benzothiazoyl Pyrazoline Derivatives containing Aromatic Heterocycle. Dyes and Pigments, 2006, 70, 246–250. (IF = 3.47)

14. Liang, J.;≠ Shi, H.; ≠ Kwok, R. T. K.; Gao, M.; Yuan, Y. Y.; Tang, B. Z*.; Liu, B*. Distinct Optical and Kinetic Responses from E/Z Isomers of Caspase Probes with Aggregation-Induced Emission Characteristics. J. Mater. Chem. B. 2014, 2, 4363–4370. (≠ Co-first author). (IF = 6.10)

15. Liu, K.; Shi, H.; Xiao, H.; Chong, A.G.L.; Bi, X.; Chang, Y. T., Tan, K.; Yada, R. Y.; Yao, S. Q*. Functional Profiling, Identification and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites. Angew. Chem. Intl. Ed., 2009, 48, 8293–8297. (IF = 11.33)

16. Loh, Y.; Shi, H.; Hu, M.; Yao, S. Q*. Click Synthesis of Small Molecule-Peptide Conjugates for Organelle-Specific Delivery and Inhibition of Lysomosal Cysteine Proteases, Chem. Commun. 2010, 46, 8407–8409. (IF = 6.72)

17. Kalesh, K.A.; Shi, H.; Ge, J.; Yao, S. Q*. The Use of Click Chemistry in the Emerging Field of Catalomics. Org. Biol. Chem., 2010, 8, 1749–1762. (IF = 3.49)

18. Sun, H.; Lu, C.H.S.; Shi, H.; Gao, L.; Yao, S. Q*. Peptide Microarrays for High-throughput Studies of Ser/Thr Phosphatases. Nat. Protocols, 2008, 3, 1485–1493. (IF = 7.78)

19. Bian, B.; Ji, S*.; Shi, H. Synthesis and Fluorescent Property of Some Novel Bischromophore Compounds containing Pyrazoline and Naphthalimide Groups. Dyes and Pigments. 2008, 76, 348–352. (IF = 3.47)

20. Ding D.; Liang, J.; Shi, H.; Kwok, R. T. K.; Gao, M.; Yuan, Y. Y.; Tang, B. Z*.; Liu, B*. Light-Up Bioprobe with Aggregation-Induced Emission Characteristics for Real-Time Apoptosis Imaging in Target Cancer Cells, J. Mater. Chem. B, 2014, 2, 231–238. (IF = 6.10)

21. Geng, J. L.; Liu, J.; Liang, J.; Shi, H.; Liu, B*. A General Approach to Prepare Conjugated Polymer Dot Embedded Silica Nanoparticles with a SiO2@CP@SiO2 Structure for Targeted HER2-Positive Cellular Imaging. Nanoscale. 2013, 5, 8593–8601. (IF = 6.74)

22. Liang, J.; Kwok, R. T. K.; Shi, H.; Tang, B. Z*.; Liu, B*. Fluorescent Light-up Probe with Aggregation-Induced Emission Characteristics for Alkaline Phosphatase Sensing and Activity Study, ACS Appl. Mater. Interf. 2013, 5, 8784–8788. (IF = 5.90)