Yu-Jie Xu, PhD
Associate Professor, School of Radiation Medicine, Soochow University，
Suzhou，Jiangsu，215006，China
Tel: 86-512-65880061, Fax: 86-512-65884830
E-mail: dbnm@suda.edu.cn, xuyuj@hotmail.com
Education Background:
Ph.D. in Radiation Medicine (Radiopharmaceuticals), Soochow University,China,2008
Department of Radiation Medicine,
M.Sc in Radiation Medicine (Radiation Immunology) , Suzhou Medical College, China,1990
B.S. in Radiation Medicine, Suzhou Medical College, China, 1985
Professional Experience:
2011-present: Associate professor, Vice Dean of School of Radiation Medicine and Protection, Medical College of Soochow University.China
2001-present: Associate professor, Department of Basic Nuclear Medicine, School of Radiation Medicine and Protection, Medical College of Soochow University, China
1999-2001: assistant professor, Department of Basic Nuclear Medicine, Suzhou Medical College, China
1998- 1999: Foreign visitor researcher, Laboratory of Biotechnology, Institute of Radiation Chemistry in Takasaki, JEARI, Japan.
1990- 1998: assistant professor, Department of Basic Nuclear Medicine, Suzhou Medical College, China
1985-1987:Assistant, Department of Radiobiology, Suzhou Medical College, China.
Research Interests:
1. to develop the special radiopharmaceuticals targeting to the ovarian and squamous epithelial cancer cell by the receptor-ligand recognition as well as Ag-Ab recognition.
2. the screening of new targeting site for imaging and therapy: 5.the role of the SPATA5L1 gene in EMT process of the normal epithelial cell and squamous epithelial, ( the radiation effect of g ray and neutron on the gene)
Research Grand as PI:
1. The study of the dopamine nanoparticle pass through the BBB. (NSFC,30270441, 2003-2005).
2. The radiation protection of the C60(OH)24- SLN-E targeting to cellular nucleus. (NSFC,30970873,2010-2012)
3. The study of X-HOPO-mAb for radioimmunotherapy of tumors overexpressing EGFR. (NSFC, 11475124, 2015-2018)
Research Experience and Accomplishments:
3. developed the special nanoparticle delivery to the cell nucleus as the scavenger of the free radicals induced by acute radiation exposure.
4. developed the special nanoparticle chelating agent of the internal contamination of radionuclides( such as 89Sr).
5. developed chemical fluorescence probe for cancer cell imaging.
Recent Publications:
6. Jia-Tao Miao, Chen Fan, Xiao-Yu Shi, Ru Sun,* Yu-Jie Xu and Jian-Feng Ge*. Colorimetric and ratiometric pH responses by the protonation of phenolate within hemicyanine. Analyst. 2014, 139, 6290-6297（IF3.9）
7. Ru Sun,?, Xiao-Dong Liu, Zhan Xuna, Jian-Mei Lu, Yu-Jie Xu, Jian-Feng Ge,? A rosamine-based red-emitting fluorescent sensor for detecting intracellular pH in live cells. Sensors and Actuators B: Chemical. 2014 (201)： 426–432（IF3.84）
8. Xiao-Dong Liu & Chen Fan & Ru Sun & Yu-Jie Xu* & Jian-Feng Ge*.Nile-red and Nile-blue-based near-infrared fluorescent probes for in-cellulo imaging of hydrogen sulfide. Anal Bioanal Chem 2014, 406:7059–7070 (PAPER IN FOREFRONT, IF 3.7, Correspondence author)
9. Jia-Tao Miao, Chen Fan, Ru Sun,* Yu-Jie Xu and Jian-Feng Ge. Optical properties of hemicyanines with terminal amino groups and their applications in near infrared fluorescent imaging of nucleoli. J. Mater. Chem. B, 2014, 2,7065-7072
10. Xiao-Dong Liu ,Ru Suna,Jian-Feng Ge,* Yu-Jie Xu*,Ying Xu, and Jian-Mei Lu*: A squaraine-based red emission off on chemosensor for biothiols and its application in living cells imaging. Org. Biomol. Chem. 2013; 11:4258-4264.(IF 3.568, Correspondence author）
11. Ru Sun, Wu Liu, Yu-Jie Xu, Jian-Mei Lu,* Jian-Feng Ge * and Masataka Ihara . Cyanobenzo[a]phenoxazine-based near infrared lysosome-tracker for in cellulo imaging. Chem. Commun. 2013, 49, 10709-10711.（IF6.378 ）
12. Xiuxiu Qi, Najun Li, * Hongwei Gu, Yujie Xu, Ying Xu, Yang Jiao, Qing feng Xu, Hua Li and Jianm ei Lu *：Amphiphilic oligomer-based micelles as cisplatin nanocarriers for cancer therapy. Nanoscale 2013, 5, 8925-8929 （IF6.233）
13. Xiao-Dong Liu, Ru Sun?, Ying Xu, Yu-Jie Xu, Jian-Feng Gea,?, Jian-Mei Lua,c,?.. A benzoxazine–hemicyanine based probe for the colorimetric and ratiometric detection of biothiols. Chemical. Sensors and Actuators B 178 (2013) 525– 531. （IF3.535）
14. Shun Yang, Najun Li,* Dong yun Chen , Xiuxiu Qi, Yujie Xu, Yin g Xu, Qingfeng Xu, Hua Lia and Jian mei Lu *. Visible-light degradable polymer coated hollow mesoporous silica nanoparticles for controlled drug release and cell imaging. Journal of Materials Chemistry B. J. Mater. Chem. B 2013, 1, 4628-4636，（IF6.101）
15. Wu Liu, Ru Sun, Jian-Feng Ge, Yu-Jie Xu, Ying Xu, Jian-Mei Lu, Isaum Itoh,and Masataka Ihara. Anal. Chem. 2013, 85，7419–7425（IF5.695）
16. Xiao Mei, Dongyun Chen, Najun Li, Qingfeng Xu, Jianfeng Ge *, Hua Li, Baixia Yang, Yujie Xu * and Jianmei Lu *. Facile preparation of coating fluorescent hollow mesoporous silica nanoparticles with pH-sensitive amphiphilic diblock copolymer for controlled drug release and cell imaging. Soft Matter. 2012, 8, 5309（IF4.75，Correspondence author）
17. Qian-Qian Zhang, Bai-Xia Yang, Ru Sun, Jian-Feng Ge *, Yu-Jie Xu *, Na-Jun Li , Jian-Mei Lu * .A near-infrared phenoxazinium-based fluorescent probe for Zinc ions and imaging in living cells. Organic & Biomolecular Chemistry. Sensors and Actuators B 171– 172 (2012) 1001– 1006（IF3.8, Correspondence author）
18. Xue-Bo Yang, Bai-Xia Yang, Jian-Feng Ge *, Yu-Jie Xu, Qing-Feng Xu *, Jie Liang,and Jian-Mei Lu *. Benzo[a]phenoxazinium-Based Red-Emitting Chemosensor for Zinc Ions in Biological Media. Organic Letters,2011,13(10):2710-2713 （IF5.5, 2区）
19. Dan Yang, Yu-Jie XU, Jie Bai, Wan-Weng WENG, Wen-Xiu DING, Cheng-Jiao HONG.The expression of the SPATA5L1、Cyclin B2 in KB cell induced by irradiation and Paclitaxel. J.Radiat.Res.Radiat.Process.2011,29(4):243-248 (Chinese, Correspondence author)
20. Wan-weng WENG, Yu-jie XU, Jian-mei WAN, Zhong-zhan WANG, Wen-xiu DING, Min LIU, Cheng-jiao HONG.Molecular mechanism of radiosensitization effect of paclitaxel .Chinese Journal of Cancer,2009,28(8):844-850（Chinese, Correspondence author）
21. Liuzhen Zhang, Yujie XU, Min LIU, WENG Wanwen, DING Wenxiu, YANG Zhanshan, Preparation and characterization of low molecular weight chitosan and high degree of deacetylation. J.Radiat.Res.Radiat.Process.2009,27(3):177-181. (Chinese, Correspondence author)
22. Xu Yu-Jie, Li Qing-Nuan,Zhu Ran, Zhu Ben-Xing,Zhang Yong-Ping,Zhang Xiao-dong, Fan Wo, Hong Cheng-Jiao, Liwen-xin: Radiotoxicity induced by Auger electron emitters in human osteosarcoma cell using comet assay. Nuclear Science and Techniques.2003,14(3):171-
23. M.Taguchi, K.Hayano, Yujie Xu, M. Moriyama, Y. Kobayashi , H. Hiratsuka, S-H Ohno: Yields of tyrosines in the radiolysis of aqueous phenylalanine solutions by energetic heavy ions. Radiation Physics and Chemistry,2001,60:263-268
24. Xu,Yu-jie editor in chief:《Experimental Nuclear Medicine》,Soochow University Press,2004
25. Zhang,QH, Tu,Yu and XU,Yu-jie editor in chief:《Radiation Protection and Safety In Clinical Medicine》，The People’s Press of Jiangsu，2007
Honors and Awards:
1. Zhan-shan Yang, Shu-Yu Zhang, Yu-Jie Xu, Jian-Ping Cao, Nan-kang Zhu, Quan-shui Shu: The study acute of radiation injury treatment technology for nuclear and radiological emergency. The second prize of technological innovation awarded by China Ministry of Education in 2014.
2. Zhan-shan Yang, Shu-Yu Zhang, Yu-Jie Xu, Jian-Ping Cao, Dao-ben Hua,Nan-kang Zhu, The research of the new treatment technology to acute radiation injury. The second prize of technological innovation awarded by China Nuclear Energy Association in 2014.
3. Zhan-shan Yang, Yu-Jie Xu, Shu-Yu Zhang, Jian-Ping Cao, Dao-ben Hua, The Biological Effect of Ionizing Radiation and the new Prevention and treatment technology of radiation injury. The second prize of science and technology progress awarded by Suzhou City Government in 2014
Patent:
Yu-Jie Xu, Min Liu, Bai-xie Yang, Jun-jie Sun: The Preparation and application of fullerol (C60(OH)24) Solid lipid nanoparticles. China,ZL201110439349.1，2014.6
Contact Information：
Mr. XU, Yu Jie
PhD, Associate Professor
Vice Dean, School of Radiation Medicine and Protection, Medical College of Soochow University
Add: Room 2315, Building 402,
Dushu Lake Campus of Soochow University,
199 Renai Road, Suzhou Industrial Park, Suzhou, Jiangsu, China (215123)
Tel:0086-512-65880061
Mobil:13913518258
e-mail: dbnm@suda.edu.cn; xuyuj@hotmail.com